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For patients on high-dose semaglutide losing significant weight, IM administration is more reliable

The mediator subunit MED16 transduces NRF2-activating signals into antioxidant gene expression

Figure S2)

While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019