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After the run-in period, patients with inadequate glycemic control (A1C 7.5% to 11%) were randomized to the addition of either 100 mg of JANUVIA or placebo, administered once daily

This could be attributed to the fact that by not using the patches for 2 days in a week (about 30% less exposure to glutathione), the subjects in Cohort 2 did not achieve adequate stimulated detoxification in all organs by glutathione over the study period

This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism