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The dual nature of Nrf2 activationprotective in normal tissues but potentially protective of tumor cells under certain conditionsdemands precise scheduling to maximize therapeutic synergy while minimizing potential interference with conventional treatments ( 6 Challenges and future perspectives Despite the compelling preclinical evidence and promising early clinical results, the full translation of SFNs potential into reliable clinical applications faces several significant challenges

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Following meningococcal vaccination, it was observed that NS workers exhibit reduced deep and REM sleep, elevated inflammatory cytokines (TNF-, IL-6), and diminished humoral immune responses

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