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We also showed that the aspirin-induced apoptosis in redox-compromised MnSOD-deficient yeast cells is associated with severe mitochondrial dysfunction, including events such as overproduction of mitochondrial superoxide radicals (O 2 ), oxidation of mitochondrial NAD(P)H 21 , decreased respiration, release of cytochrome c and disruption of the mitochondrial membrane potential 20

Acknowledgements This work was supported in part by grants to P.F

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