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The typical research protocol escalates doses: Notice how the units per dose climb as the dose escalates

We chose the SD rat IVC stenosis-induced DVT model as it is suitable for the study of clinical thrombotic disorders 48 , the mechanism of which is partial stagnation of blood through incomplete ligation of the inferior renal veins of both kidneys 14 , which is more similar to incomplete thrombosis due to hemodynamic alterations in the clinic 49

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