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AOD-9604 failed Phase 2 not due to safety concerns but because the magnitude of fat loss versus placebo, while statistically significant, was too modest to meet the efficacy threshold for a standalone obesity treatment
Dietary Broccoli Protects against Fatty Liver Development but Not against Progression of Liver Cancer in Mice Pretreated with Diethylnitrosamine
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This isn't just academic detailthe specific geometry of the copper complex determines its biological activity and explains why other copper-peptide combinations don't show the same effects
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