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If the duration of continuous operation following regeneration begins to consistently shorten, it indicates that the resin may be fouled or that the regeneration parameters require adjustment

Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

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Should additional safety concerns be identified, Health Canada will take appropriate action to protect the health and safety of Canadians and communicate updates, if needed