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Table 2 Development studies with five DPP-4 inhibitors: number of examined subjects and placebo-adjusted change in HA1c when DPP-4 inhibitors were added to drug-nave subjects with type 2 diabetes or as add-on to metformin, sulfonylurea, thiazolidinediones, or insulin in placebo-controlled 24 or 26 week studies

The small GTPase Rab7 regulates the transport of autophagosomes and promotes their interaction with lysosomes (Wang et al., 2016)