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There are uneven shape irregular edges variance in color or discoloration larger than the size of a pencil erases change in size, contour, or coloration itching or seeping a sore that doesnt heal coloring that spreads from the spot to the surrounding skin redness of swelling that spreads to the surrounding skin pain, tenderness, or itchiness texture change in the mole such as scaliness, oozing, bleeding, or the appearance of a lump

Similarly, individuals with higher body mass index may experience greater absolute weight loss, though percentage body weight reduction remains relatively consistent across BMI categories

Very similar type study

For the appropriate patient, the barrier is most often the monthly copays and costs without insurance coverage