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10.1186/s12964-025-02308-7 Summary Keywords mtDNA mutagenesis, oxidative stress, Ames bacterial mutagenicity test, triage theory, mitochondrial dysfunction, aging, nutrition Citation Dang J, Liou JY, Mullah R and Giulivi C (2025) The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives