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Preventing atherosclerosis In a study that examined the effects exerted by liraglutide on the endothelium in mice models with early onset, low-burden atherosclerotic disease, liraglutide treatment in apolipoprotein E deficient (ApoE / ) mice inhibited the progression of early onset, low-burden atherosclerotic disease and enhanced plaque stability in a partially GLP-1R-dependent manner, without significantly affecting late onset, high-burden atherosclerotic disease