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may be repeated or increased as required Acute Pulmonary Edema * Usually 2040 mg IV initially Adverse Effects Electrolyte Disturbances * Hypokalemia * Hyponatremia * Hypomagnesemia * Hypocalcemia Other * Dehydration * Hypotension * Dizziness * Hyperuricemia (may precipitate gout) * Ototoxicity (especially with high IV doses) Contraindications * Severe dehydration * Anuria * Severe electrolyte depletion * Hypersensitivity to furosemide Monitoring * Fluid balance * Blood pressure * Renal function * Serum electrolytes (especially potassium) * Daily weight in patients with edema Drug Interactions * Digoxin (risk increased with hypokalemia) * Aminoglycosides (increased ototoxicity) * NSAIDs (may reduce diuretic effect) * Lithium (increased lithium toxicity) * Furosemide is a loop diuretic acting on the thick ascending limb of the loop of Henle