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High concentrations appear in wound fluid, blood platelets, and areas of active tissue remodeling

He presented with an intra-oral brown macular lesion on the left buccal mucosa with a duration of one and a half months

Activators At the transcriptional level, NFE2L2 gene is induced by several transcription factors, including the aryl hydrocarbon receptor (AhR) in response to environmental pollutants like polycyclic aromatic hydrocarbons, breast cancer susceptibility gene 1 (BRCA1) in response to xenobiotic stress, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) in response to inflammatory stimuli

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