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Oligomeric -synuclein is increased in basal tears of Parkinsons patients
Acrylic acid, an inhibitor of -oxidation pathway, inhibits the 3-ketoacyl-CoA thiolase activity [36, 37] when used at zero hours in the presence of 2-EH or 2-EHA (0.4 mg mL 1 ) in MSM, no growth of the test organism was detected, which confirmed the involvement of -oxidation pathway
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Interestingly, this treatment combined with either sirtinol or olaparib enhanced the sensitivity of the cells against FK866 both in mass cultures and tumorspheres, suggesting that these combinations can be used to reduce the toxic effects of NAMPT inhibition during the incorporation of a more effective therapy
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