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Additionally, a meta-analysis of multiple randomized, controlled trials confirmed that tesamorelin treatment significantly lowered visceral fat area and trunk fat, reduced hepatic fat, and was associated with a statistically significant increase in lean body mass, supporting its clinical effect on fat distribution and muscle preservation

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In a pooled metanalysis of major placebo-controlled trials, Sattar et al found a 12% reduction in all-cause mortality and 14% relative risk reduction in 3-point MACE