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Preclinical and cell culture research has examined exogenous glutathione for its capacity to replenish intracellular GSH pools under oxidative stress conditions, modulating Nrf2/ARE pathway activity and mitochondrial redox balance

In adult clinical trials for weight reduction, allergic reactions occurred in 8 of 50 treated patients with antidrug antibodies and in 114 of 1659 treated patients who did not develop antidrug antibodies