Combination therapy may provide enhanced skin brightening results
For example, in a 3-week prospective intervention with a high dose of 100 mg riboflavin/day with 70 patients with Crohns Disease, a reduction in systemic oxidative stress (measured by higher free thiol plasma levels), inflammatory markers (IL-2 and C-reactive protein (CRP)) and clinical symptoms of Crohns disease (i.e., a reduction in clinical disease activity index and quality of life improvement) were observed 52
Although the results support a beneficial effect for antioxidants overall and the subgroup analysis suggested the potential for pycnogenol and L-arginine to improve erectile function, additional research is needed to evaluate and isolate the effect of specific antioxidant products
Kardos J, Samu J, Ujszszi K, Nagy J, Kovcs I, Visy J, Maksay G, Simonyi M