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It is noteworthy that compared with ERS agonist alone, the combination of ferroptosis inhibitor and ERS agonist can significantly reduce the incidence of ERS and cardiomyocyte injury, while ferroptosis agonist can aggravate cardiac dysfunction

The pivotal trials enrolled hundreds of subjects and used CT-measured visceral adipose tissue (VAT) as the primary endpoint, a harder measure than BMI or waist circumference

PTL toxicity was reduced in co-cultures containing stromal cells and fibroblasts but not to the same extent as cultures containing MSC ( Online Supplementary Figure S4A )

Journal of Pharmaceutical Sciences .