Weve covered this topic in much greater detail in our article on Melanotan 2 and hair pigmentation changes
Rapid weight loss itself is also a pancreatitis risk factor
As for Alpha Yohimbine(or Rauwolscine) It seems to have a slightly different pharmacological profile then Y and in some ways seems more effective, for this 1 mg is a good starting dose, I cant comment too much on it but it looks like a good ingredient and I would like to try it at some point as I am still trying to figure out if it has more or less side effects
Wu H, Guo H, Liu H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2020) Copper sulfate-induced endoplasmic reticulum stress promotes hepatic apoptosis by activating CHOP, JNK and caspase-12 signaling pathways