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Pharmacokinetic studies demonstrated approximately 38% oral bioavailability and blood-brain barrier penetration, unusual for a peptide-based compound and attributable to Dihexa's small size (504.66 Da) and hydrophobic modifications

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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Capehorn MS, Catarig AM, Furberg JK, Janez A, Price HC, Tadayon S, Vergs B, Marre M

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A 2025 systematic review published in an orthopedic sports medicine journal noted that adverse effects from unregulated manufacturing depict a genuine safety concern independent of the peptide itself

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