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Of those, 20 participants who were high TMAO producers and met all other inclusion criteria progressed to Phase II, with 16 completing the full study (Figure 1)
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Since multiple comparisons were made, only p values less than 0.01 are listed
Most of the research in these areas comes from in vitro or animal studies, and there are no high-quality clinical trials consistently showing cosmetic or lifespan-extending effects in people.33 34 66 A few small studies suggest topical ALA may offer modest benefits for skin appearance, but these findings are early and so far dont apply to oral supplementation.35 Youre using ALA for weight loss You take certain medications ALA can interact with several medications.39 These include drugs for diabetes (like insulin or metformin), thyroid medications (like levothyroxine), and certain chemotherapy agents such as alkylating agents and antitumor antibiotics
