The body composition effects of the amylin analogs in humans are unknown but there is animal evidence that they spare lean mass
Clinically, it is primarily used for the treatment of type 2 diabetes mellitus to lower fasting and postprandial glucose levels and HbA1c, with additional applications in chronic weight management for obese or overweight patients
Figure 13 In conclusion, through a variety of tests (cell lines, tissue cultures, in vivo animal models, IHC including at the electron micrograph level, imaging) and clinical trials (scintigraphy imaging, drugdrug interactions), oral semaglutide co-formulated with SNAC has been shown to be absorbed in the stomach in a localized, transient, transcellular process, where a local increase in pH provides solubility and protection against enzymatic degradation
Discuss dose reduction experiments with your provider once you reach goal weight and maintain it for several months