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The isoelectric point of a solution is reached when the positive and negative charges of amphoteric ions are equal

This includes cleavage of the E-peptide by intracellular proteases of the pro-protein convertase family to release mature IGF-I for secretion 20 , maintenance of pro-IGF-I to be secreted without cleavage 2124 , or N-glycosylation in the E-peptide of the predominant IGF-I isoform (IGF-IA) 25 , and then secretion

So CT-388s effect could grow in future readouts for the Phase II trial

On the other hand, Wegovy contains the active ingredient semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist