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A real-world analysis of approximately 8,000 patients from the Cleveland Clinic found considerably less weight regain than clinical trial data would predict largely because many real-world patients transition to another weight-loss agent, restart semaglutide, or maintain structured lifestyle interventions after stopping

It requires subcutaneous injection and is often used alongside other diabetes treatments like insulin or sulfonylurea

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Further subgroup analysis revealed that, compared to diabetic populations, semaglutide had a more significant reduction in SBP ( 1.87, 95% CI 2.67 to 1.06, vs 5.02, 95% CI 6.10 to 3.94) and DBP ( 0.43, 95% CI 0.89 to 0.02, vs 1.96, 95% CI 3.12 to 0.80) in non-diabetic populations