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Similarly, the research team found that membrane G protein-coupled bile acid receptor 5 (TGR5) enhances mitophagy and inhibits mitochondrial fission by regulating the PKC /Drp1-HK2 signaling pathway in HG-induced human retinal endothelial cells (RMEC) and STZ induced SD rat models, thus having a certain therapeutic effect on retinal dysfunction [160]

In the same study the rate of retained gastric contents was also 3.3% in those without diabetes (although only 150 out of 815 patients were not diabetic)

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