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Additionally, treatment with 10 nM E2, for 7 days, stimulated differentiation to the neuronal lineage, and inhibited differentiation to astrocytes (Zhang et al., 2019)

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Some researchers theorize that the GIP component may actually help moderate some of the harsher GI effects of GLP-1 activation, which could partially explain why retatrutide compared to other agents does not always show proportionally worse GI profiles despite having three active mechanisms

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