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Fluoroquinolones require monitoring for both hypoglycemia and hyperglycemia, particularly in patients with diabetes, as noted in an FDA Drug Safety Communication

The safety of OZEMPIC tablets (1.5 mg, 4 mg and 9 mg strengths) [see Dosage and Administration (2.2)] and RYBELSUS (3 mg, 7, mg and 14 mg strengths) [see Dosage and Administration (2.2)] has been established as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus based on adequate and well-controlled studies of RYBELSUS in adult patients with type 2 diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14)]

The pen's internal mechanism automatically accounts for this concentration, so patients simply select their prescribed dose in milligrams on the dose counter

Supplementation is often necessary during extended semaglutide use