His key contributions include: Discovery and initial characterization of MOTS-c as the first mitochondrial-encoded nuclear transcription regulator Demonstration of MOTS-c as an exercise-induced factor that improves age-dependent physical decline Elucidation of bi-genomic communication mechanisms between mitochondrial and nuclear genomes Investigation of MOTS-c polymorphisms associated with longevity in specific populations Studies on MOTS-c effects across aging, metabolic disease, and neurological applications His laboratory continues to investigate molecular mechanisms underlying MOTS-c function, therapeutic potential in age-related diseases, and translational applications for human health and longevity
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In some cases, this takes place without the knowledge or involvement of patients primary care physicians (PCPs), complicating a main function of primary care, which is to oversee care coordination, and prevent and treat chronic diseases like obesity
GLP-1Drugs and Eating Disorders The physician, who doubles as Chief Development Officer at Ovid Therapeutics, a biopharmaceutical company focusing on neurological conditions, calls for doctors to consider the link between the neuropsychiatric origins of eating disorders and the current understanding of how GLP-1RAs work on the brain
