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In particular, pharmacokinetic/pharmacodynamic analyses of semaglutide suggest an approximately linear exposureresponse relationship for weight reduction, in contrast to the more saturable response observed for glycemic endpoints

These include: Heart-related conditions: Conditions such as high blood pressure (hypertension), coronary artery disease, heart valve disease, heart failure, and previous heart attacks can lead to tachycardia

Significant weight loss, through an effect to reduce energy intake, led to the approval of liraglutide (3.0 mg) for the treatment of obesity, an indication currently under investigation with semaglutide