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Subsequent work established that the peptide was naturally complexed with copper in plasma and that both the peptide and the copper were necessary for its biological effects

This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

Improved tolerance: Starting with smaller doses could help patients adjust to the medication more easily

A short, simple peptide might survive a sloppy synthesis