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The review followed the guidelines outlined in the Joanna Briggs Institute Reviewers Manual and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews)

A: MT-2 binds to four of the five known melanocortin receptor subtypes: MC1R (expressed on melanocytes and skin cells), MC3R (brain, gut, and immune tissue), MC4R (hypothalamus associated with energy homeostasis research), and MC5R (exocrine glands and immune tissue)

Glutamate: This non-essential amino acid acts as a neurotransmitter in the central nervous system