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The serine deprivation-dependent induction is regulated by the activating transcription factor 4 (ATF4) and can be reversed by the addition of glycine and serine, but not by other amino acids like leucine or cysteine (Hamano et al., 2020)

Mathematical model and data fitting The overall dynamics involving the interaction of GSH with glucose can be summarily represented as: That is, GSH neutralizes ROS produced during glycolysis and converts to the disulfide form, GSSG

In clinical, a prolonged survival by metformin was only observed in diabetic PDA patients and no effect was found in the whole PDA population, which indicates the major effect of metformin is decreasing insulin resistance rather than anticancer effect ( (3)

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