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Based on its extensive biochemical mechanisms, buffered ascorbic acid may help manage a wide array of symptoms associated with complex chronic illnesses: Severe Fatigue and Post-Exertional Malaise (PEM): By acting as a mandatory cofactor for carnitine synthesis, vitamin C ensures that fatty acids can enter the mitochondria for ATP production, directly supporting cellular energy levels and helping to mitigate the deep exhaustion that follows physical or cognitive exertion

Data availability We are grateful for mapping software by Figdraw in producing figures, and no extra data was used for the research described in the article

Furthermore, ferroptosis has been shown to exacerbate renal tubular injury via the HIF-1/ Heme Oxygenase-1 (HO-1) pathway in diabetic mice (134)

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