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Michelle Brown 2 , Bonita Basnyat 2 , Jennifer Dine 2 1 Ionis Pharmaceuticals, Carlsbad, California, USA, 2 RTI Health Solutions, Research Triangle Park, North Carolina, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2032 Aims Severe hypertriglyceridemia (sHTG) and familial chylomicronemia syndrome (FCS) are characterized by high triglyceride levels associated with negative impacts on physical, emotional, social, and cognitive function

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Lack of Clinical Evidence Critical gaps in knowledge: Zero randomized controlled trials on microdosing GLP-1 agonists No long-term safety data for alternative dosing regimens Unknown effects on cardiovascular outcomes Potential for reduced efficacy not captured in models 2

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