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Screening and identification of the main metabolites of Schisantherin a in vivo and in vitro by using UHPLC-Q-TOF-MS/MS

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FIGURE 4 FIGURE 5 3.3 L-carnitine counteracted lenvatinib-induced protein synthesis inhibition in C2C12 myocytes We have shown that lenvatinib inhibits global protein synthesis in C2C12 myocytes at concentrations 100 nM, which is equivalent to the trough plasma concentration in patients with HCC (Supplementary Figure S1)

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