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Treatment of PV and other myeloproliferative disorders has improved dramatically in recent years with the use of newer drugs such as Janus kinase (JAK) inhibitors, which can help prevent PV from advancing to more aggressive diseases such as acute myeloid leukemia, myelofibrosis, or myelodysplastic syndromes

Astrocytes are capable of producing both pro-inflammatory and anti-inflammatory cytokines, such as IL-6 [358], and the bidirectional communication between astrocytes and microglia is central to shaping the inflammatory milieu within the CNS

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Glutathione works as an antioxidant in the body by neutralizing free radicals and reducing oxidative stress