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Tailoring a molecule to this specific purpose requires a substantial understanding of how the current class of GLP-1R agonists access and interact with the satiating and aversive neuronal receptor populations

45 Remarkably, the recent SELECT trial proved the cardiovascular efficacy of subcutaneous semaglutide in reducing the primary cardiovascular composite endpoint (death from cardiovascular causes, non-fatal MI or non-fatal stroke) in both overweight and obese patients with established atherosclerotic CVD

Conclusions Hypothyroidism is widely recognized as a significant risk factor for MASLD

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