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doi: 10.1194/jlr.M051680 10 YangTNianYLinHLiJLinXLiTet al

The secreted a-MSH then binds to the melanocortin 1 receptor (MC1R) on nearby melanocytes

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Clinical trial data shows headaches occur in approximately 3-8% of semaglutide users, with most experiencing mild tension-type headaches rather than severe migraines