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These modifications play a crucial role in regulating gene expression by altering the chromatin structure

Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, Bleichert S, Saleh L, Knfler M, Zeisler H, Hengstschlger M, Rosner M, Salzer H, Gundacker C (2015) Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects

In evolutionary terms, it is a way of saying enough. If you then layer on therapies like exogenous insulin, you can temporarily force glucose down, but you havent changed the reason the resistance developed in the first place