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Bazan, 2004) and levels of lipid peroxide and reactive oxygen species (ROS) (Hashimoto et al., in vitro and in vivo (Lim et al., 2001

For instance, while quercetin has been reported to activate both enzymes, curcumin has shown potential as an activator of SIRT1, promoting its deacetylase activity and contributing to anti-inflammatory effects 178

In Vitro 51 , 1122 (2018)

In Arabidopsis, SIR is encoded by a single, essential gene and is described as a bottleneck in the sulfate assimilation pathway ( SIR expression is rapidly upregulated in Arabidopsis and tomato in response to higher sulfite content, and accordingly SIR activity increases (Yarmolinsky et al., 2013)