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Protein quantification was carried out using the MaxLFQ algorithm as implemented in the DIA-NN R package ( and the number of peptides quantified in each protein group was counted as implemented in the DiannReportGenerator package ( 71

Patients on warfarin should consult their GP or anticoagulation clinic before starting CoQ10, and INR (International Normalised Ratio) monitoring should be performed after starting, stopping, or changing CoQ10 dose, with warfarin dosing adjusted as needed