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It was shown that L-theanine (600 g/mL) could induce apoptosis of tumor cells through the mitochondrial pathway in human HepG2 hepatoblastoma cells and HeLa adenocarcinoma cells ( in vitro , ex vivo , and in vivo HHC models, and the mechanism of this effect was that L-theanine and DTBrC blocked the Met/EGFR/vascular endothelial growth factor receptor (VEGFR)-Akt/NF-B pathways ( In addition, L-theanine can also be used as an auxiliary measure to reduce some side effects of cancer treatment

doi: 10.1016/b978-0-12-800100-4.00003-9 114 Purves-TysonTDRobinsonKBrownAMBoerrigterDCaiHQWeisslederCet al

cdc.gov/diabetes/php/data-research/index.html Centers for Disease Control and Prevention