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If Sleep Is the Main Concern, Start With the Cause Sleep difficulty is a symptom, not a single diagnosis

Patients on tirzepatide were twice as likely to lose at least 25% of their body weight, and nearly one in five (19.7%) lost 30% or more, compared to fewer than one in fourteen (6.9%) on semaglutide.[1] Both medications also improved blood pressure, blood sugar, and cholesterol levels, with greater improvements seen in the tirzepatide group, which tracked with the larger weight reduction.[1] The safety profiles were similar

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Genetic Factors That May Influence GLP-1 Treatment Readiness Individual response to GLP-1 medications involves genetic variation in GLP-1 receptor function, glucose-dependent insulinotropic peptide (GIP) signaling, appetite regulation, and fat metabolism