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HIF1a suppresses tumor cell proliferation through inhibition of aspartate biosynthesis

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2 Here, we present a comparative live cell binding analysis of three distinct ligand classes targeting the GLP-1R overexpressed in HEK293 cells: the small molecule orforglipron (an FDA-approved GLP-1R agonist), the peptide semaglutide (a widely studied GLP-1 analog for weight loss and inflammation), and an anti-GLP-1R monoclonal antibody directed against the extracellular domain (ECD)