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Although, there was an initial rise in GFR (32%), RPF (28%) and the percentage of tubular reabsorption of filtered phosphate at day 4, all these parameters returned to baseline levels after 13 or 20 days of rhIGF-1 treatment, but the patients developed severe side effects, including jaw pain, nasal congestion and Bells palsy, requiring discontinuation of rhIGF-1 treatment in 4 of 9 patients