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Upregulation or modulation of genes involved in the ergosterol biosynthetic pathway (ERG family), as well as modifications to sterol content, may alter the binding or activity of polyenes, and in the case of azoles, change the abundance of the target enzyme (lanosterol 14-demethylase), which affects its activity

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They demonstrated that administration of curcumin-loaded SLNs in TgCRND8 mice inhibited the expression of TG2-S, thereby reducing the activation of the apoptotic pathway