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Although the trial is not a conclusive verdict on semaglutides efficacy for addiction due to the small patient pool, and the results are far short of what would be needed for the FDA to formally approve the GLP-1 drugs use in alcohol use disorder, it does provide encouragement for companies who are thinking of testing their drugs in the indication in the not-so-distant future

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While not often measured, the GLP-1/GLP-2 ratio (detecting C-terminal of GLP-1 and N-terminal of GLP-2) remains consistent throughout an oral fat tolerance test, but interestingly significantly increases at 120 and 250 min during an OGTT in obese men (Matikainen et al., 2016)

tirzepatide's 20.9% came at 72 weeks