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3.6 Potential Microbiome Changes GLP-1 receptor agonists alter: Gastric motility Transit time Food intake patterns Emerging research suggests that weight loss and altered dietary intake may influence gut microbiota composition. At present, there is insufficient evidence to conclude that GLP-1 drugs independently cause clinically significant microbiome-mediated nutrient depletion

However, these drugs have several pleiotropic and lipid-independent actions [1924]

Uncontrolled hypertension - Bupropion may raise blood pressure, especially in patients whose high blood pressure is poorly controlled

The application of the gut health concept based on objective, measurable parameters will therefore remain incomplete as long as we remain unable to comprehensively define normality and to reliably predict clinical scenarios and patient outcomes from physiological measures alone