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Archives of gynecology and obstetrics

16, 17 In addition, in cultured vascular smooth muscle cells (VSMCs) and isolated arteries from hypertensive rats and humans, ROS production is enhanced, redox-dependent signaling is amplified, and antioxidant bioactivity is reduced

Important safety considerations include risk of pancreatitis (stop treatment and seek urgent care if severe persistent abdominal pain radiating to the back occurs), gallbladder disease , diabetic retinopathy complications (especially with rapid improvement in blood glucose control), and risk of acute kidney injury with dehydration

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