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Estradiol modulates thermogenesis at three points on this VMH-SNS-BAT pathway: 1) through its effects on the VMH nucleus 2) through its effects on SNS signaling 3) directly through its effects on BAT

Glucagon-like peptide 1 (GLP-1) is a naturally occurring hormone produced by the body that helps to regulate blood sugar levels and plays a key role in controlling the level of satiety one feels after one eats